GEORGE HYND,NICHOLAS CHARLES RAY,HARRY FINCH,DAVID MIDDLEMISS,MICHAEL COLIN CRAMP,PAUL MATTHEW BLANEY,KAREN WILLIAMS,YAN GRIFFON,TREVOR KEITH HARRISON,PETER CRACKETT
申请号：
BRPI0622197
公开号：
BRPI0622197A2
申请日:
2006.12.21
申请国别(地区):
BR
年份:
2012
代理人:
摘要：
CRTH2 ANTAGONISTS. The following compounds are CRTH2 antagonists, useful in the treatment of respiratory diseases: [3- (2,4-dichlorophenylsulfanyl) -6-fluoro-2-methylindolizin-1-yl] acetic acid, [6-fluoro-3 - (2-fluoro-4-methanesulfonyl phenylsulfanyl) -2-methylindolizin-1-yl] acetic acid, [6-fluoro-3- (4-methanesulfonyl-2-trifluoromethylphenylsulfanyl) - 2-methylindolizin-1-yl] acetic acid, (R) -2- [6-fluoro-3- (4-methanesulfonylphenylsulfanyl) -2-methylindolizin-1-yl] propionic acid, [3- (4-ethanesulfonylphenylsulfanyl) -6-fluoro-2-methylindolizin-1- yl] acetic, (S) -2- [6-fluoro-3- (4-methanesulfonylphenylsulfanyl) -2-methylindolizin-1-yl] propionic acid, (ethanesulfonylaminobenzenesulfonyl) -6-fluoro-2-methylindolizin-1-yl ] acetic, [7-chloro-6-fluoro-3- (4-methanesulfonylphenylsulfanyl) -2-methylindolizin-1-yl] acetic acid, [3- (2-chloro-4-methanesulfonylphenylsulfanyl) -7-cyano-2 -methylindolizin-1-yl] acetic, [6-cyano-3- (4-methanesulfonylbenzyl) -2-methylindolizin-1-yl] acetic acid uric, [3- (4-chlorobenzyl) -7-cyano-2-methylindolizin-1-yl] acetic acid, [6-cyano-3- (6-fluoroquinolin-2-yl-methyl) -2-methylindolizin- 1-yl] acetic, [6-fluoro-3- (4-methoxyphenylsulfanyl) -2-methylindolizin-1-yl] acetic acid, [7-chloro-6-fluoro-3- (4-methoxyphenylsulfanyl) -2- methylindolizin-1-yliacetic acid, [3- (4-bromophenylsulfanyl) -6-fluoro-2-methylindolizin-1-yl] acetic acid, and [3- (4-cyclopropyl sulfamoylphenylsulfanyl) -6-fluoro-2-methylindolizin- 1-yl] acetic.ANTAGONISTAS DE CRTH2. Os compostos que se seguem são antagonistas de CRTH2, úteis no tratamento de doenças respiratórias: ácido [3-(2,4-diclorofenilsulfanil)-6-fluoro-2-metilindolizin-1-il]acético, ácido [6-fluoro-3- (2-fluoro-4-metanossulfonil fenilsulfanil)-2-metilindolizin-1-il]acético, ácido [6-fluoro-3- (4-metanossulfonil-2-trifluorometilfenilsulfanil) - 2-metilindolizin-1-il]acético, ácido (R)-2-[6-fluoro-3-(4-metanossulfonilfenilsulfanil) -2-metilindolizin-1-il]propiônico, ácido [3-(4-etanossulfonilfenil
