1. Use in medicine, especially as the target country of Trk. Requirement 1: a formula compound (1) or its acceptable salt, wherein R1 is h, or C1-5 tar, which can be replaced by up to three independently selected substitutes from Oh, r5r6；So2r7, sr7, R7, CH2OH, co2r5, sonr7r7, nr7so2r5, CN, NO2 and R8, or a selected cyclopentadiene c3-5, propilanio, or a saturated acyclic ring with four to six members, cyclopentadiene system has at most three heteroatoms selected from n, O and s, The system eliminates this alternative, with up to three alternatives selected independently from methyl, oh, and (r5r6),So2r7, R7, CH2OH, co2r5, son7r7, nr7so2r5, CN, NO2 and R8； R2 is h or methyl； R3 is h, NH2 or NH (c1-3 tar), which can be selectively replaced by up to three alternatives selected from Oh and O (c1-3 tar)；R101 is h, O H, my, cyclopapile, methoxi, ethio, etoxi o CN； X is a link, O, (ch-r4) n, Nr104, ocha2 or CH2O； R4 is independent h, CH3, CH2OH, CH3, CH2OH, oh, NH3, n (CH3) 2, ch2nh2, ch2ch3, or CH2n (CH3) 2； r104 is h, asphalt c1-3, or carbohydrate C4-6, Each of these alternatives is replaced by up to three independently selected alternatives from c1-3, CH2OH and NH2 tar； n is 1 or 2； R102 is a ring system consisting of 3 to 7 members of a single ring, carbocnic or heterocycle system, or 8 to 14 members of a double cycle system, which can be saturated or Partially or completely unhealthyThe ring heteromorphic system can have at most five heteroatoms of the ring selected from n, s and O. in the ring, the double ring ring system can include two rings (carbocycle, carbocycle heterocycle, heterocycle - carbocycle or heterocycle - heterocycle), which are combined or connected by simple links； The epoxy system can be selectively replaced by up to three independent substitutes, which can be replaced from halo, CN, nr5r6, so2r7, sr7, C1-4 tar, up to three oh and / or alcoxi c1-3, cyclopentyl-c3-6 groups, and up to three oh and / or alcoxi c1-3 groups, if feasible,C1-3 optional t
