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Methods and systems for identifying and treating anti-progestin sensitive tumors
专利权人:
INVIVIS PHARMACEUTICALS INC.
发明人:
Gilles Erard
申请号:
NZ71789012
公开号:
NZ717890A
申请日:
2012.10.04
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
Discloses the use of an anti-progestin composition in the preparation of a medicament for the treatment of a tumor susceptible to growth inhibition by one or more anti-progestin(s), wherein the tumor is identified as susceptible to growth inhibition by one or more anti-progestin(s) wherein a) a tissue sample suspected of being tumorigenic from a patient is exposed to an anti-progesterone receptor antibody b) flow cytometry is performed on the tissue sample to identify progesterone receptor positive cells c) high magnification microscopy is used to identify activated progesterone receptor foci in the progesterone receptor positive cells and d) the focal binding distribution of the progesterone receptor in nuclei of cells from the tissue is determined, wherein if the focal binding distribution is greater than 5% of the progesterone receptor positive cells in the tissue sample with an A or AD binding pattern, then the tumor is determined to be susceptible to growth inhibition by one or more anti-progestin(s).
来源网站:
中国工程科技知识中心
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