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Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals
专利权人:
Gary McCort;Pascale Goberville;Henning Steinhagen;Bodo Scheiper;Guillaume Begis;Hans Matter;Berangere Thiers
发明人:
Henning Steinhagen,Bodo Scheiper,Hans Matter,Gary McCort,Guillaume Begis,Pascale Goberville,Berangere Thiers
申请号:
US13353889
公开号:
US08415336B2
申请日:
2012.01.19
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib,wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.
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