GRAHAM MICHAEL WAYNE,FRENCH PETER,ZHU YORK YUANYUAN,LU YIXIANG,LI TIEJUN,SUN YUNCHENG,TANG XIAOJUN,SHAN LI
申请号：
IN4681/DELNP/2013
公开号：
IN2013DN04681A
申请日:
2013.05.27
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention the agents have more than one effector sequence wherein the multiple effectors may target the same region of an HBV gene different (possibly overlapping) regions of the same gene and/or different HBV genes.
