肾祖细胞
- 专利权人:
- 昆士兰大学
- 发明人:
- 梅利莎·利特尔,高里实
- 申请号:
- CN201480045180.3
- 公开号:
- CN105473706A
- 申请日:
- 2014.06.13
- 申请国别(地区):
- CN
- 年份:
- 2016
- 代理人:
- 摘要:
- 提供了一种用于同时生产肾单位祖细胞和输尿管上皮祖细胞的方法,其包括使间介中胚层细胞与以下物质接触的步骤:成纤维细胞生长因子9和/或成纤维细胞生长因子20,和任选的选自以下的一种或多种:骨形态形成蛋白7;肝素;Wnt激动剂;视黄酸;和RA拮抗剂。可以操作Wnt激动剂、视黄酸和/或RA拮抗剂的浓度,以有利于肾单位祖细胞和输尿管上皮祖细胞的相对生产。所述间介中胚层细胞最终经由后原条阶段从人多能干细胞衍生出。所述肾单位祖细胞和输尿管上皮祖细胞可能具有最终用途诸如用于肾修复和再生、肾的生物打印和筛查化合物的肾毒性。
- 来源网站:
- 中国工程科技知识中心
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