Daniel Scherman,Michel Bessodes,Corinne Chaneac,Didier Louis Gourier,Jean-Pierre Jolivet,Quentin Le Masne De Chermont,Serge Maitrejean,Fabienne Sylvie Pelle
申请号：
US12091571
公开号：
US08709383B2
申请日:
2006.10.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.
