New pharmaceutical composition (I), comprises: (1) insulin (and/or its analog, derivative and/or active metabolite)； (2) surfactant(s)； and (3) optionally one or more components selected from preservatives, isotonic agents, buffers and other auxiliaries. (I) contains little or no zinc. An independent claim is also included for the preparation of (I). ACTIVITY : Antidiabetic. MECHANISM OF ACTION : None given in the source material.
