United States Patent salts bicyclic compound derivative, or a pharmaceutically acceptable comprising a pyrimidine ring, a manufacturing method thereof, to provide pharmaceutical compositions, and their use containing it. Bicyclic compound derivative or a pharmaceutically acceptable salt thereof comprising the pyrimidine ring according to The invention relates, by acting as 5-HT 4 receptor agonist , gastrointestinal motility disorders, for example, reflux esophagitis (GERD), constipation, irritable bowel syndrome, dyspepsia, post-operative ileus, delayed gastric emptying disease, stomach paralysis, intestinal pseudo-obstruction disease, drug-induced pass delay disease , or it can be usefully applied in the prevention or treatment of digestive system diseases such as diabetic stomach atony.BACKGROUND【課題】ピリミジン環を含む二環式化合物誘導体またはその薬学的に許容される塩、その製造方法、それを含む薬学的組成物、及びその用途を提供する。【解決手段】本発明に係るピリミジン環を含む二環式化合物誘導体またはその薬学的に許容される塩は、5-HT4レセプターアゴニストとして作用することにより、胃腸管運動障害、例えば、逆流性食道炎(GERD)、便秘、過敏性腸症候群、消化不良、術後イレウス、胃排出遅延症、胃麻痺症、偽性腸閉塞症、薬物誘発性通過遅延症、または糖尿病性胃アトニーなどの消化器系疾患の予防または治療に有用に適用できる。【選択図】なし
