ALLEN J. EBENS,BRIAN E. TOKI,MARK X. SLIWKOWSKI,PAUL POLAKIS,PETER D. SENTER,SUSAN D. SPENCER,SVETLANA O. DORONINA,TONI BETH KLINE
申请号：
BR122018071808
公开号：
BR122018071808B1
申请日:
2004.11.05
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to auristatin peptides, including meval-val-dil-dap-norephedrine (mmae) and meval-val-dil-dap-phe (mmaf), which have been prepared and linked to ligands through various connectors, including maleimidocaproil -val-cit-pab. the present invention also relates to the resulting drug-ligand conjugates that were active in vitro and in vivo.a presente invenção se refere a peptídeos auristatina, incluindo meval-val-dil-dap-norefedrina (mmae) e meval-val-dil-dap-phe (mmaf), que foram preparados e ligados a ligantes através de vários conectores, incluindo maleimidocaproil-val-cit-pab. a presente invenção também se refere aos conjugados de droga-ligante resultantes foram ativos in vitro e in vivo.
