Oligonucleotide compounds containing non-nucleotide overhangs

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专利权人:

クォーク ファーマシューティカルズ インコーポレーティッド

发明人:

アヴキン－ナチュム シャロン,フェインスタイン エレナ,アヴキン-ナチュム シャロン

申请号：

JP2012548108

公开号：

JP5824463B2

申请日:

2011.01.06

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions.

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