Be used to prevent and treat the method and composition of the impaired and/or degeneration CNS of experience CNS cell forfeiture or death.Various embodiment of the present invention is applied to 1/3rd places on the nasal cavity by intranasal and at least a therapeutic cell that will treat effective dose is transported to CNS, thereby walks around blood brain barrier.Pharmaceutical composition of the present invention can comprise at least a therapeutic cell, at least a delivery enhancer, at least a antibiotic, at least a regulator and/or at least a immunosuppressant, and wherein said compositions is delivered to last 1/3rd places of nasal cavity.In case be delivered to CNS, described therapeutic cell priority migration is to impaired or degeneration or injured zone.
