BAUMHOF PATRICK,KRAMPS THOMAS,VOSS SÖHNKE,KALLEN KARL JOSEF,FOTIN MLECZEK MARIOLA
申请号：
IN5848DEN2014
公开号：
IN5848DEN2014A
申请日:
2014.07.14
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention is directed to a pharmaceutical composition including (e.g. for use as an adjuvant) a polymeric carrier cargo complex comprising as a carrier a polymeric carrier formed by disulfide crosslinked cationic components； and as a cargo at least one nucleic acid molecule and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease； an antigen associated with allergy or allergic disease； an antigen associated with autoimmune disease； or an antigen associated with a cancer or tumour disease or in each case a fragment variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits as well as the use of the pharmaceutical composition or the kit as a vaccine particularly in the treatment of infectious diseases allergies autoimmune diseases and tumour or cancer diseases.
