MARTINEZ, IGNACIO,ARMEN, ZACHARY GARO,CEZAR, CHRISTINE,MARTIN, BARRY ANDREW,AVENDANO AMADO, MAIER STEVE
申请号：
CA3047357
公开号：
CA3047357A1
申请日:
2018.01.24
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in humans.
