The present invention provides an oligonucleotide comprising the sequence of 5'-GGAACAGTTCGTCCATGGC-3' (SEQ ID NO: 2) for use in the treatment of inflammatory bowel disease in a human subject, wherein 150 mg-350 mg of said oligonucleotide is provided. Individual doses are administered to the subject on at least two separate occasions, wherein the separate occasions are three weeks apart. [Selection diagram] Figure 1本発明はヒト被験者における炎症性腸疾患の治療において使用するための、５'-ＧＧＡＡＣＡＧＴＴＣＧＴＣＣＡＴＧＧＣ-３'（配列番号２）の配列を含むオリゴヌクレオチドを提供し、ここで前記オリゴヌクレオチドの１５０ｍｇ～３５０ｍｇの個々の用量が少なくとも２つの別々の機会に該被験者に投与され、ここで前記別々の機会は３週間離れている。【選択図】図１
