The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/ TGF-beta-1 /Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.本發明係關於包括人類抗體及其抗原結合部分之抗體,該等人類抗體及其抗原結合部分與類活化素受體激酶-1(ALK-1)之胞外域(ECD)結合,且對ALK-1/TGF-β-1/Smad1信號傳輸路徑具消除作用。本發明亦係關於衍生自人類抗ALK-1抗體之重鏈及輕鏈免疫球蛋白,及編碼該等免疫球蛋白之核酸分子。本發明亦係關於製造人類抗ALK-1抗體之方法、包含該等抗體之組合物及使用該等抗體及組合物之方法。本發明亦係關於包含本發明之核酸分子之轉殖基因動物或植物。