Disclosed is the use of a composition, wherein said composition comprises, essentially consists of, or consists of: (a) a particle, wherein said particle is a virus-like particle of an RNA bacteriophage and (b) an immunostimulatory nucleic acid, wherein said immunostimulatory nucleic acid is an unmethylated CpG containing oligonucleotide wherein said particle is packaged with said immunostimulatory nucleic acid, and wherein said composition is free of an allergen or an allergen extract, and wherein said composition is formulated for administration to said animal without administration of an allergen or allergen extract in the manufacture of a medicament for treating hypersensitivity in an animal, wherein said hypersensitivity is an allergy, asthma or dermatitis.
