Heterocyclic and cyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase

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专利权人:

Dennis L Wright

发明人:

Dennis L Wright,Amy C Anderson,Grant Sormunen

申请号：

US14620997

公开号：

US09382213B2

申请日:

2015.02.12

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Compounds of Formula I and Formula IA are inhibitors of dihydrofolate reductase and are suitable for use in compositions and methods for dihydrofolate reductase inhibition or, more specifically, treatment of a fungal infection, a bacterial infection or a protozoal infection, and, in specific embodiments, treatment of a fungal infection caused by C. albicans or C. glabrata:wherein R, R1, R2, R3, R4, A, B, E, V, W, X, Y and Z are as defined herein.

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