Purushottam V. Gawande;Gord Froehlich;Karen LoVetri;Srinivasa Madhyastha;Nandadeva Yakandawala
发明人:
Karen LoVetri,Srinivasa Madhyastha,Nandadeva Yakandawala,Purushottam V. Gawande,Gord Froehlich
申请号：
US14355308
公开号：
US20150087582A1
申请日:
2012.06.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.
