TERRETT, JONATHAN ALEXANDER,LU, LI-SHENG,KING, DAVID JOHN,CARDARELLI, JOSEPHINE M,PAN, CHIN,HUANG, HAICHUN,COCCIA, MARCO A
申请号：
NZ56639506
公开号：
NZ566395A
申请日:
2006.09.26
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an isolated monoclonal antibody or antigen binding portion thereof comprising: a) a heavy chain variable region CDR1 comprising SEQ ID NO: 11； b) a heavy chain variable region CDR2 comprising SEQ ID NO: 16； c) a heavy chain variable region CDR3 comprising SEQ ID NO: 21； d) a light chain variable region CDR1 comprising SEQ ID NO: 26； e) a light chain variable region CDR2 comprising SEQ ID NO: 31； and f) a light chain variable region CDR3 comprising SEQ ID NO: 36. Also disclosed is the use of the antibody for the preparation of a medicament for the treatment or prevention of a disease characterized by growth of tumor cells expressing CD70 in a subject.
