DALLY, ROBERT, DEAN,HUANG, JIANPING,JOSEPH, SAJAN,SHEPHERD, TIMOTHY, ALAN,HOLST, CHRISTIAN L
申请号：
NZ58042308
公开号：
NZ580423A
申请日:
2008.05.01
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
A compound according to formula (I) where the substituents R1, R2, R4, R5, Y, Z1 and Z2 are as defined in the claims. The compound can be 4-{ 4-[4-(4-fluoro-3-rifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl} -1H-pyrazolo[3,4-d]pyrimidine or the compound 4-{ 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl} -1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate. The compound is a p70 S6 kinase inhibitor and can be used for the inhibition of angiogenesis and the treatment of adenocarcinomas.
