Mueller Bernhard,Huang Lili,Bardwell Philip D.,Kutskova Yuliya,Memmott John
申请号：
NZ71448213
公开号：
NZ714482A
申请日:
2013.01.25
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is an isolated antibody which binds to Repulsive Guidance Molecule a (“RGMa”), wherein the antibody comprises a variable heavy region comprising a complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO:2 (SHGIS), a CDR2 comprising the amino acid sequence of SEQ ID NO:3(WISPYSGNTNYAQKLQG), and a CDR3 comprising the amino acid sequence of SEQ ID NO:4(VGSGPYYYMDV), and a variable light region comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:6(TGTSSSVGDSIYVS), a CDR2 comprising the amino acid sequence of SEQ ID NO:7(DVTKRPS), and a CDR3 comprising the amino acid sequence of SEQ ID NO:73(YSYAGTDTL).
