John J. Nemunaitis,Neil Senzer,Phillip B. Maples,Donald Rao,P‧B‧梅普爾斯,D‧拉奧
申请号：
HK19100699
公开号：
HK1258331A1
申请日:
2019.01.16
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-&bgr； through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
