A compound of formula (I) R-L-CO-X (I) (wherein R is a C10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO2, said hydrocarbon group comprising at least 4 non-conjugated double bonds； L is a linking group forming a bridge of 1 to 5 atoms between the R group and the carbonyl CO； and X is an electron withdrawing group) for use in the treatment of rheumatoid arthritis.
