Mice that produce antigen-binding proteins with pH-dependent binding characteristics

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专利权人:

Regeneron Pharmaceuticals; Inc.

发明人:

McWhirter, John,MacDonald. Lynn,Murphy, Andrew J.

申请号：

AU2013204580

公开号：

AU2013204580A1

申请日:

2013.03.15

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013204580A120131003.pdf#####Docket No. 7700A-WO ABSTRACT Genetically modified non-human animals are provided that comprise an immunoglobulin heavy chain locus comprising an unrearranged human heavy chain variable region nucleotide sequence comprising an addition of at least one histidine codon or a substitution of at least one endogenous non-histidine codon with a histidine codon. Compositions and methods for making the genetically modified nonhuman animals as described herein are provided. Non-human animals capable of expressing an antigen-binding protein characterized by pH-dependent antigen binding, enhanced recyclability and/or enhanced serum half-life are also provided. 116

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