PERA, MARTIN FREDERICK,BEN-HUR, TAMIR,REUBINOFF, BENJAMIN EITHAN
申请号：
CA2403000
公开号：
CA2403000C
申请日:
2001.03.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to undifferentiated human embryonic stem cells,methods of cultivation and propagation and production of differentiated cells.In particular it relates to the production of human ES cells capable ofyielding somatic differentiated cells in vitro, as well as committedprogenitor cells such as neural progenitor cells capable of giving rise tomature somatic cells including neural cells and/or glial cells and usesthereof. In one aspect of the present invention, there is provided an enrichedpreparation of undifferentiated human embryonic stem cells capable ofproliferation in vitro and differentiation to neural progenitor cells, neuroncells and/or glial cells. This invention provides a method that generates anin vitro and in vivo model of controlled differentiation of ES cells towardsthe neural lineage. The model, and the cells that are generated along thepathway of neural differentiation may be used for the study of the cellularand molecular biology of human neural development, for the discovery of genes,growth factors, and differentiation factors that play a role in neuraldifferentiation and regeneration, for drug discovery and for the developmentof screening assays for teratogenic, toxic and neuroprotective effects.
