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RADIOTRACER FOR ALZHEIMER'S DISEASE
专利权人:
UNIVERSITE DE LORRAINE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人:
YVES CHAPLEUR,SANDRINE LAMANDE-LANGLE,CHARLOTTE COLLET,FRANCOISE CHRETIEN
申请号:
FR1253109
公开号:
FR2989088B1
申请日:
2012.04.04
申请国别(地区):
FR
年份:
2014
代理人:
摘要:
The invention relates to a compound of formula (I), where: n is an integer equal to 0 or 1; R1 is, when n=0, an alkyl chain having 3 to 6 carbon atoms, an alkenyl chain, alkylene, a linear hydroxyalkyl chain having 2 to 6 carbon atoms, the hydroxyl function optionally being protected or the oxygen of said function being substituted so as to form a leaving group, a halogenoalkyl chain having 2 to 6 carbon atoms, the halogen optionally being radioactive, or a fluoromethyl group, the fluorine optionally being radioactive, and when n=1, a monohydroxyalkyl chain having 1 to 6 carbon atoms, the hydroxyl function, at the terminal position, optionally being protected or the oxygen of said function being substituted so as to form a leaving group, or monohalogenoalkyl having 1 to 6 carbon atoms, the halogen at the terminal position optionally being radioactive, wherein the halogen is not bromine; P1 is, when n=0, hydrogen or a group protecting the hydroxyl function, identical or different, when n=1 and R1 is a monohydroxyalkyl chain, hydrogen or a group protecting the hydroxyl function, identical or different, and when n=1 and R1 is a monohalogenalkyl chain, hydrogen or a group protecting the hydroxyl function, identical or different; Y1 is, when n=0, an OP1 group, where P1 is as defined above, or, when n=1, a hydrogen atom, with the exception of the non-radiolabeled 2-fluoromethyl-myo-inositol compounds for which P1, identical or different, is a hydrogen atom or a benzyl protecting group, and to the use thereof as a drug.
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