The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia.本發明係關於一種具對人類CD52結合專一性的人類化免疫球蛋白、老鼠單株抗體及嵌合抗體，本發明進一步係關於一種人類化免疫球蛋白輕鏈及人類化免疫球蛋白重鏈，本發明亦關於包含編碼人類化免疫球蛋白或免疫球蛋白輕鏈或重鏈的序列的分離核酸、重組載體及宿主細胞，及關於一種製備人類化免疫球蛋白的方法。該人類化免疫球蛋白可用於醫療應用以治療，例如，自體免疫疾病、癌症、非-何杰金氏淋巴瘤、多發性硬化症及慢性淋巴性白血病。
