Drug delivery device adapted to receive a cartridge and comprising a housing, a front-loaded cartridge holder adapted to receive and hold a cartridge in a loaded position, and stop means adapted to engage a proximal surface of a received cartridge The stop means is actuatable between a receiving state in which the stop means is positioned in a first axial position thereby defining how far proximally a received cartridge can be inserted, and an operational state in which the stop means allows an inserted cartridge to be moved axially to a second more proximal position.
