Pegylated Interleukin-10

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

Seoju Lee,David C. Wylie,Susan Cannon-Carlson

申请号：

US14186954

公开号：

US20140227223A1

申请日:

2014.02.21

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.

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