8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME

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专利权人:

Linda Chia-Hui Yu

发明人:

Ling-Wei Hsin,Linda Chia-Hui Yu,Tsung-Chun Lee

申请号：

US16490070

公开号：

US20200071274A1

申请日:

2018.03.02

申请国别(地区):

US

年份:

2020

代理人:

摘要：

A series of 8-phenyl-isoquinoline derivatives (I) exhibit high binding affinity to 5-HT7 receptor (5-HT7R) and demonstrate potent antinociceptive activity in two animal models for Irritable Bowel Syndrome (IBS) by intraperitoneal injection (i.p.) or by oral administration (p.o.). These 5-HT7 receptor antagonists are a new class of therapeutic agents for the treatment of IBS.

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