BAUMHOF PATRICK,VOSS SÖHNKE,KRAMPS THOMAS,KALLEN KARL JOSEF
申请号:
IN11341/DELNP/2012
公开号:
IN2012DN11341A
申请日:
2012.12.28
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention is directed to a polymeric carrier cargo complex comprising as a cargo at least one nucleic acid (molecule) and disulfide crosslinked cationic components as a (preferably non toxic and non immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells and and/or for induction of an (innate and/or adaptive) immune response preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides pharmaceutical compositions particularly vaccines and adjuvants comprising the inventive polymeric carrier cargo complex and optionally an antigen as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell a tissue or an organism for (gene )therapeutic purposes as disclosed herein and/or as an immunostimulating agent or adjuvant e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition adjuvant or vaccine in one or more parts of the kit.