Zuniga-Pflucker, Juan Carlos,Awong, Geneve,La Motte-Mohs, Ross
申请号：
AU2009311232
公开号：
AU2009311232B2
申请日:
2009.11.06
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD 1a-CD5- or CD34+CD7+CDla-CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
