The present invention relates to compositions and methods for preventing,treating or delaying various cardiovascular diseases or disorders in mammals,particularly in humans. More particularly, the present invention provides forcompositions and methods for preventing, treating or delaying variouscardiovascular diseases or disorders using, inter alia, a neuregulin protein,or a functional fragment thereof, or a nucleic acid encoding a neuregulinprotein, or a functional fragment thereof, or an agent that enhancesproduction and/or function of said neuregulin.