Pierre Druilhe,Giampietro Corradin,Ali Jafarshad,Christian Roussilhon
申请号：
US12991414
公开号：
US20120164167A1
申请日:
2009.05.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present application relates to a sub-region of a Plasmodium protein, with improved vaccine potential, and to medical uses thereof, notably for treatment or diagnosis of malaria. The present invention notably provides unstructured or unfolded polypeptides deriving from the PFF0165c protein of P. falciparum 3D7. The polypeptides of the invention have a high anti-genicity, a high immunogenicity, have a high parasite-killing activity in the ADCI assay, and are strongly associated with clinical protection against malaria, and. The present invention thereby provides a vaccine for the palliative and/or curative treatment of malaria, which is specifically intended for infants, toddlers, children under the age of 5, pregnant women.
