Pena Rossi, Claudia,Littau, Alisa M.,Wallis, Wayne J.,Zuckerman, Linda,Graffner, Hans Otto Lennart,Van Ness, Kirk P.,Holdren, Matthew S.,Ponce Jr., Rafael A.
申请号：
AU2008230777
公开号：
AU2008230777B8
申请日:
2008.03.27
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibitionand immunosuppressants for the treatment of autoimmune diseases. One preferredmethod is where the BLyS and/or APRIL antagonist is a Fc-fusion protein whichcan be a TACI-Fc-fusion protein comprising the extracellular domain of TACIor a functional fragment thereof, a BAFF-R-Fc-fusion protein comprising theextracellular domain of BAFF-R or a functional fragment thereof, or a BCMA-Fc-fusionprotein comprising the extracellular domain of BCMA or a functional fragmentthereof. In the methods of the present invention some of the immunosuppressivedrugs contemplated include cyclophosphamide (CYC), azathioprine (AZA), cyclosporineA (CSA), or mycophenolate mofetil (MMF), although any drug that suppresses theimmune system may be suitable. The methods of the present invention reduce thelevels of various immunoglobulins in patients in need of such reduction, suchas those suffering from autoimmune diseases.
