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A CONCENTRATED ANTIBIOTIC FORMULATION AND A SOLUTION
专利权人:
发明人:
NAKAJIMA HIROFUMI,MACHIDA HARUHIKO
申请号:
IN532/CHENP/2009
公开号:
IN277141B
申请日:
2009.01.29
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
Abstract: Disclosed is a pharmaceutical composition for injection purposes, which comprises WAP-8294A2 (a depsipeptide-type antibiotic) as an active ingredient, which is stable, and which contains WAP-8294A2 in a high concentration. Specifically, disclosed is a pharmaceutical composition for injection purposes, which comprises WAP-8294A2 having the structure represented by the formula (1) as an active ingredient and 2-hydroxypropyl-&bgr-cyclodextrin or &bgr-cyclodextrin as a stabilizing agent or a solubilizer, and whose pH value is not adjusted. Also disclosed is a solution for injection comprising WAP-8294A2,which can be prepared by mixing the pharmaceutical composition with a pH-adjusting agent comprising a solution containing disodium hydrogen phosphate, monosodium dihydrogen phosphate and sodium hydroxide and an infusion or a diluent such as dextrose just before use. (1)
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