Indolin-2-one derivatives as protein kinase inhibitors

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专利权人:

Annji Pharmaceutical Co.; Ltd.

发明人:

CHERN, Ji-Wang,JAGTAP, Ajit Dhananjay,WANG, Hsiao-Chun,CHEN, Grace Shiahuy

申请号：

ES13777764

公开号：

ES2600467T3

申请日:

2013.04.03

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound of Formula A: ** Formula ** or a pharmaceutically acceptable salt thereof, (I) in which: R3 is hydrogen, aryl (C6-C18), halo-aryl (C6-C18), or alkoxy (C1 -C6) -aryl (C6-C18)； Rb is hydrogen, (C3-C18) heteroaryl, (C1-C6) alkoxy (C3-C18) heteroaryl； (C1-C6) alkyl (C3-C18) heteroaryl, (C1-C6) alkyl-(C1-C6) alkoxy (C3-C18), alkyl (C1-C6) -carboxyalkyl (C1-C6) -heteroaryl (C3-C18)； (C1-C6) alkyl - (C1-C6 alkylamino) -C1-C6 alkylcarbamoyl) (C3-C18) heteroaryl, (C1-C6) alkyl-(C6-C18) -aryl (C3-C18) heteroaryl , (C1-C6) alkyl-C1-C6 alkoxycarbonyl (C3-C18) heteroaryl, (C1-C6) alkyl-C1-C6 alkoxy-oxyalkyl (C1-C6) -heteroaryl (C3-C18), (C1-C6) alkyl-heterocyclylcarbonyl (C3-C6) -heteroaryl (C3-C18), (C1-C6) alkyl-heterocyclyl (C3-C6) -oxyalkyl (C1-C6) -heteroaryl (C3-C18), or (C1-C6) alkyl - (heterocyclyl (C3-C6) - alkylcarbamoyl (C1-C6)) - heteroaryl (C3-C18)； Rc is hydrogen, alkoxybenzoylureido (C1-C6), or halo-aryl (C6-C18) -heteroarylamide (C3-C18)； Rd is hydrogen, halogen, alkoxybenzoylureido (C1-C6), or halo-aryl (C6-C18) -heteroarylamide (C3-C18)； Re is benzoylureido, halobenzoylureido, halo-alkoxybenzoylureido (C1-C6), alkoxybenzoylureido (C1-C6), alkylaminobenzoylureido (C1-C6), alkylbenzoylureido (C1-C6), nitrobenzoylureido, haloalkylbenzoylureido (C1-C6 alkyl-halo-C1-C6 alkyl halo ), halo-arylcarbamoylacetamide (C6-C18), alkoxy (C1-C6) - arylcarbamoylacetamide (C6-C18), alkoxy (C1-C6) -arylcarbamoyl (C6-C18) -cycloalkylamido (C3-C6), halo-aryl ( C6- C18) -heteroarylcarbonylamino (C3-C18), cycloalkyl (C3-C6) -heteroarylcarbonylamino (C3-C18), alkylamino (C1-C6) - aryl (C6-C18) -heteroarylcarbonylamino (C3-C18), halo-alkoxy (C1-C6) -aryl (C6-C18) -heteroarylcarbonylamino (C6-C18), alkoxy (C1-C6) -aryl (C6-C18) -heteroarylcarbonylamino (C3-C18), alkyl (C1-C6) -heteroarylcarbonylamino ( C3- C18), aryl-heteroarylcarbonylamino (C3-C18), haloalkyl (C1-C6) halo-aryl (C6-C18) -heterocyclylcarbonylamino (C3-C6), haloalkyl (C1-C6) -aryl (C6-C18) - heteroarylcarbonyla

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