A method of forming a probability map is disclosed. According to one embodiment, a method may include: (1) obtaining multiple measures of multiple imaging parameters for every stop of a moving window on an image, wherein two neighboring ones of the stops of the moving window are partially overlapped with each other； (2) obtaining first probabilities of an event for the stops of the moving window by matching the measures of the imaging parameters to a classifier； and (3) obtaining second probabilities of the event for multiple voxels of a probability map based on information associated with the first probabilities.
