EVANS, HELEN L.,STRUNTZ, NICHOLAS B.,CHEN, ANDREW,KOEHLER, ANGELA N.,STEFAN, ERIC,CABALLERO, FRANCISCO,NEEL, DYLAN VIJITH
申请号：
CA3012846
公开号：
CA3012846A1
申请日:
2017.02.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure provides compounds of Formula (I'), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits.
