KANG, JAE SEONKR,강재선,JUNG, CHUNG KIKR,정충기,LEE, SEO HYUNKR,이서현,KANG, JUN HOKR,강준호,CHOI, JAE KIKR,최재기,PYO, JAE SUNGKR,표재성
申请号：
KR1020150171734
公开号：
KR1017176720000B1
申请日:
2015.12.03
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention provides an injection or an eye-drop agent produced as a homogeneous solution by solubilizing a poorly soluble active pharmaceutical ingredient. The injection or the eye-drop agent is produced by mixing a poorly soluble material which is dissolved in alcohol and is not dissolved in water a detergent for dispersing the poorly soluble material and a solubilizing agent for dissolving the poorly soluble material in a solvent (water). The poorly soluble material has an active pharmaceutical ingredient, and includes poorly soluble ginseng saponin (compound K molecular weight 622.878), dexamethasone (molecular weight 392.45), decursin (molecular weight 328.35), and decursinolangelate (molecular weight 328.35), which have molecular weights of 1000 or less, and cyclosporin (molecular weight 1202), which has a molecular weight of 2000 or less and has a cyclic structure therein. The solubilizing agent is used twice more than the poorly soluble material, and the poorly soluble material is dissolved in a solvent (water), so a homogeneous solution is produced. Moreover, preferably, the solubilizing agent includes any one or a mixture of histidine, lysine, or arginine which is alkaline amino acid, and the solubilizing agent is added to be two or more times greater than the poorly soluble material. Accordingly, a homogeneous solution containing a poorly soluble medicine is produced, and thus an injection or an eye-drop agent which does not have a side effect is provided without precipitation and eduction of a medicine.COPYRIGHT KIPO 2017본 발명은, 유효한 약리 성분을 가지되, 1000이하의 분자량을 가지는 난용성 인삼사포닌 (컴파운드 케이의 분자량 622.878), 덱사메타손(분자량 392.45), 데커신(분자량 328.35),데커시놀안젤레이트(분자량 328.35), 2000이하의 분자량을 가지되 구조에 환구조를 가지는 사이클로스포린(분자량 1202)로 이루어지는 물질로 알콜에는 용해되고 물에는 용해되지 않는 난용성 물질과, 상기 난용성물질의 분산을 위한 디터전트와, 용매(물)에 상기 난용성물질을 용해시키는 가용화제를 혼합하여 이루어지되, 상기 가용화제는 상기 난용성 물질의 양에 대하여 2배이상 사용되도록 함으로써 용매(물)에 난용성 물질이 용해되어 균질용액으로 이루어지도록 하는 난용성 유효 약리성분을 가용화시켜 균질용액으로 형성되는 주사제 또는 점안용 제제를 제공하는데 그 기술적 특징이 있다
