The purpose of the present invention is to provide a compound having an exceptional JAK1 inhibitory effect. Examples of the present invention include pyrazolothiazole compounds represented by general formula [I], and pharmacologically acceptable salts thereof. Compounds of the present invention have JAK1 inhibitory activity. Given this JAK1 inhibitory activity, compounds of the present invention also have an immunosuppressive effect (against, e.g., rheumatoid arthritis, inflammatory bowel disease, psoriasis, vasculitis), an anti-inflammatory effect (against, e.g., bronchial asthma, chronic obstructive pulmonary disease, eosinophilic sinusitis, nasal polyps), an antiproliferative effect, and the like.La presente invención se refiere a un compuesto de pirazolotiazol de la fórmula [I], o una sal del mismo farmacéuticamente aceptable: (ver Fórmula) El compuesto de la invención tiene actividad inhibidora de JAK1, y de este modo, efecto inmunosupresor, efecto anti-inflamatorio y efecto anti-proliferativo, y es útil en el tratamiento de las enfermedades, por ejemplo, artritis reumatoide, enfermedad inflamatoria intestinal, psoriasis y vasculitis, asma bronquial, enfermedad pulmonar obstructiva crónica y sinusitis eosinofílica, pólipo nasal.
