BUROVA ELENA,MUJICA ALEXANDER O,LAI KA MAN VENUS,MURPHY ANDREW J
申请号：
IN201617042825
公开号：
IN201617042825A
申请日:
2016.12.15
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Non human animals and methods and compositions for making and using the same are provided wherein said non human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. Said non human animals may be described in some embodiments as having a genetic modification to an endogenous Pdcd1 gene so that said non human animals express a PD 1 polypeptide that includes a human portion and an endogenous portion (e.g. a non human portion).
