The invention relates to a pharmaceutical composition comprising cis-(E)-4-(3-fluorophenyl)-2',3',4',9'-tetrahydro-N,N-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1'[1H]- pyrido[3,4-b]indol]-4-amine. The pharmaceutical composition is suitable for topical administration, especially for intravesical administration in the treatment of bladder pain.