A kit for treatment of acne vulgaris, said formulation of the kit effectively inhibiting or killing Proprionibacterium without antibiotics. A preferred formulation alleviates the four pathogenic factors of acne.In a preferred method using the kit, a first skin-wash formulation comprising a higher zinc pyrithione concentration than the second leave-on formulation is applied to the affected area and subsequently washed off the skin with water. Then, a second leave-on formulation, preferably comprising a minimum of 0.25% zinc pyrithione with additional ingredients for eliminating or reducing other pathogenic factors of acne vulgaris, is applied to the skin.The kit includes a skin-wash component and a leave-on component comprising the acne treatment of the invention. Formulations are preferably applied as creams, lotions or emulsions.
