Systems and methods for control of a medical data processing system are provided. Some embodiments are particularly directed to presenting a user interface for control of an IVUS imaging system. In one embodiment, a method comprises: presenting a set of mode options to a user at a user display device receiving a mode selection selected by the user determining a set of operating parameters based on the mode selection receiving, by a medical processing system, a first set of medical sensing data and processing, by the medical processing system, the first set of medical sensing data according to the operating parameters. The determining may be further based on at least one of a previous mode selection, a user preference, an operative course of a medical procedure, patient information, the first set of medical sensing data, a second set of medical sensing data, a status indicator, and a sensing device identifier.