JUNG Sung Youb;HWANG Sang Youn;KWON Se Chang;HANMI PHARM. CO. LTD.;CHOI In Young;KIM Seung Su
发明人:
JUNG Sung Youb,HWANG Sang Youn,KWON Se Chang,CHOI In Young,KIM Seung Su,JUNG Sung Youb,HWANG Sang Youn,KWON Se Chang,CHOI In Young,KIM Seung Su
申请号：
IL24926416
公开号：
IL249264A
申请日:
2016.11.28
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
A composition for preventing or treating diabetes mellitus includes insulin and a GLP-1/glucagon dual agonist. The composition can inhibit the weight gain and reduce the danger of hypoglycemia due to the administration of insulin, lower the administration dose and greatly improve the compliance of drugs through a combined administration of a long-acting insulin conjugate and a long-acting GLP-1/glucagon dual agonist conjugate. In addition, the long-acting insulin conjugate and the long-acting GLP-1/glucagon dual agonist conjugate can improve the in vivo sustainability and stability because an insulin and a GLP-1/glucagon dual agonist are linked to the immunoglobulin Fc region via a non-peptidyl linker. A method for preventing or treat diabetes mellitus includes administration of the insulin and a GLP-1/glucagon dual agonist.
