GIORDANI, Antonio,MANDELLI, Stefano,PORTA, Francesca,GHIRRI, Matteo,ROVATI, Lucio
申请号：
HUE10731576
公开号：
HUE037631T2
申请日:
2010.06.04
申请国别(地区):
HU
年份:
2018
代理人:
摘要：
The present invention relates to the solid state of 6-(1H-imidazol-1-yl)-2-phenylquinazoline (I) and therefore to novel crystalline forms of the base and of pharmaceutically acceptable salts and solvates thereof, and also to methods for preparing them, to the respective pharmaceutical formulations and to their therapeutic use. Compound (I) may be obtained as the free base in five different crystalline forms, three polymorphic forms and two hydrates. Some pharmaceutically acceptable salts of (I) that have physicochemical characteristics acceptable for pharmaceutical development were obtained, and the respective polymorphic forms and/or hydrates were characterized.
