MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
发明人:
HERRMANN, BERNHARD,BAUER, HERMANN
申请号：
CA2618198
公开号：
CA2618198C
申请日:
2006.08.11
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a method for producing a transgenic non humanmale animal, preferably a mammal, fish, bird or insect, wherein thetransgene(s) confer(s) a change in the transmission ratio of (a) genetictrait(s) to the offspring of said non human male animal, preferably mammal,fish, bird or insect to a non-Mendelian ratio, said method comprisingintroducing (a) a first nucleic acid molecule encoding an expression productwith a Responder function into a chromosome of a non-human germ cell,(fertilized) egg cell, embryonic cell or a cell derived therefrom, of the samespecies as the transgenic male to be prepared, said chromosome containing orconferring said genetic trait(s), thereby linking on said chromosome saidResponder function to the genetic trait(s)； and (b) at least one secondnucleic acid molecule encoding an expression product with a Distorter functioninto (a) chromosome(s) of a non-human germ cell, (fertilized) egg cell,embryonic cell or a cell derived therefrom, of the same species as thetransgenic male to be prepared, wherein said expression product with aDistorter function is a factor involved in G protein signaling, wherein saidfirst nucleic acid molecule encoding an expression product with Responderfunction and said at least one second nucleic acid molecule encoding anexpression product with a Distorter function are introduced into the same ordifferent chromosomes.
