PROTHENA BIOSCIENCES LIMITED;THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA
发明人:
TAMIE J. CHILCOTE,JASON GOLDSTEIN,WEI PING GAI,JOHN P. ANDERSON
申请号：
PT10189868
公开号：
PT2361928T
申请日:
2004.05.19
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in trycine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue (117) and before residue (126) of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
